Autonomic Disorders Consortium

Information for Patients and Families

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Pure Autonomic Failure (PAF)

What is Pure Autonomic Failure (PAF)?

Pure autonomic failure (PAF) is a peripheral degenerative disorder of the autonomic nervous system.

Symptoms include:

Who gets PAF?

PAF is most frequently seen in men, in middle to late life.

What causes PAF?

The cause of PAF is not completely known.

How is PAF diagnosed?

In addition to asking detailed questions about the patient’s health, the physician will conduct a physical examination, which will include checking blood pressure and heart rate while the patient is sitting, standing and after one minute of being upright.

What is the treatment for PAF?

PAF is considered a generally mild condition. Treatments for PAF focus on managing symptoms: