Clic Logo Clic - Cholestatic Liver Diesase Consortium

CLiC Cholestatic Liver Disease Consortium

Participaiting Clinical Centers

Children's Memorial Hospital

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Children's Memorial Hospital

Contact Information:

Peter Whitington, MD
CLiC Site Principal Investigator
E-mail: p-whitington@northwestern.edu

Estella Alonso, MD
CLiC Co-Investigator

Hector Melin-Aldana
CLiC Pathologist

Sue Kelly, RN
Study Coordinator
E-mail: SKelly@childrensmemorial.org
 773.868.8931

Krista Tuzinkiewicz
Study Coordinator
E-mail: ktuzinkiewicz@childrensmemorial.org
773.975.8523

Current Studies:

6001: Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis

Useful Links:

Children's Memorial Hospital Department of Gastroenterology, Hepatology and Nutrition

Children's Memorial Hospital Liver Transplant Program

Publications:

  1. Whitington PF, Whitington GL. Partial external diversion of bile for the treatment of intractable pruritus associated with intrahepatic cholestasis. Gastroenterology, 1988;95:130-6.
  2. Harrison HH, Miller KL, Whitington PF. Improved detection, via ISO-DALT two dimensional electrophoresis, of "low Z expressor" individuals with alpha-1-antitrypsin MZ phenotype. Clin Chem 1990;36:1850.
  3. Tonsgard JH, Stephens J, Rhead WJ, Penn D, Horwitz AL, Kirschner BS, Whitington PF, Berger S, Tripp ME. Laboratory and pathologic findings in a patient with a defect in fatty acid metabolism. Pediatr Neurol 1991;7:125-30.
  4. Whitington PF, Freese DK, Alonso EM, Fishbein MH, Emond JC. Progressive familial intrahepatic cholestasis (Byler's Disease). In, Lentze MJ, Reichen J, eds, Paediatric cholestasis. Novel approaches to treatment. Falk symposium No. 63. Dordrecht, The Netherlands, Kluwer Academic, 1992:165-80.
  5. Whitington PF, Freese DK, Alonso EM, Schwarzenberg SJ, Sharp HL. Clinical and biochemical findings in progressive familial intrahepatic cholestasis. J Pediatr Gastro Nutr 1994;18:134-41.
  6. Alonso EM, Snover D, Whitington PF, Montag A, Freese DK. Histologic pathology of progressive familial intrahepatic cholestasis. J Pediatr Gastro Nutr 1994;18:128-33.
  7. Shneider BL, Setchell KDR, Whitington PF, Neilson KA, Suchy FJ. D 4 -3-Oxosteroid-reductase deficiency presenting as neonatal liver failure and hemochromatosis. J Pediatr 1994;124:234-8.
  8. Loret de Mola O, Burnweit C, Whitington PF. Chronic pruritus and cholestasis. Internat Pediatr 1995;10:233-5.
  9. Rand EB, Spinner NB, Piccoli DA, Whitington PF, Taub R. Molecular analysis of 24 Alagille syndrome families identifies a single submicroscopic deletion and further localizes the Alagille region within 20p12. Hum Genet 1995;57:1068-73.
  10. Emond JC, Whitington PF. Surgical management of progressive familial intrahepatic cholestasis. J Pediatr Surg 1995;30:1635-41.
  11. Whitington PF. Chronic cholestasis of childhood. Pediatr Clin No Amer 1996;43:1-26.
  12. Alonso EM, Allen KJ, Whitington PF. Progressive familial intrahepatic cholestasis. In: Broelsch CE, Burdelski M, Rogiers X, eds, Cholestatic liver diseases in children and adults. Dordrecht, The Netherlands, Kluwer Academic, 1996:22-30.
  13. Rebhandl W, Felberbauer FX, Turnbull J, Paya K, Barcik U, Huber WD, Whitington PF, Horcher E. Biliary diversion by use of the appendix (cholecystoappendicostomy) in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 1999; 28:217-9.
  14. Emerick KM, Whitington PF. Clinical aspects of familial cholestasis (with molecular explanations). Curr Gastroenterol Rep 1999;1:223-30.
  15. Whitington PF, Emerick KM, Suchy FJ. Familial hepatocellular cholestasis. In: Suchy FJ, Sokol RJ, Balistreri WF, eds, Liver Disease in Children (second edition). Philadelphia : Lippincott, Williams and Wilkins 2001:315-26.
  16. Emerick KM, Whitington PF. Molecular basis of neonatal cholestasis. Pediatr Clin No Amer 2002;49:221-35.
  17. Emerick KM, Whitington PF. Partial external biliary diversion for intractable pruritus and xanthomas in Alagille syndrome. Hepatology 2002;35:1501-6.
  18. Rabinowitz SS, Gelfond D, Chen C-K, Gloster ES, Whitington PF, Sacconi S, Salviati L, DiMauro S. Hepatocerebral mitochondrial depletion syndrome: Clinical and morphologic features of a nuclear gene mutation. J Pediatr Gastroenterol Nutr. 2004;38:216-20.
  19. Emerick KM, Krantz ID, Kamath BM, Darling C, Burrowes DM, Spinner NB, Whitington PF, Piccoli DA. Intracranial vascular abnormalities in Alagille patients. J Pediatr Gastroenterol Nutr 2005;41:99-107.