Clic Logo Clic - Cholestatic Liver Diesase Consortium

CLiC Cholestatic Liver Disease Consortium

Participaiting Clinical Centers

The Children's Hospital, Denver

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13123 East 16th Avenue
Aurora, CO 80045

The Children's Hospital Web Site
The Children's Hospital is affiliated with the University of Colorado at Denver and Health Sciences Center

Contact Information:

Ronald Sokol, MD
CLiC Principal Investigator
The Children's Hospital and University of Colorado Health Sciences Center
E-mail: sokol.ronald@tchden.org

Michael R Narkewicz, MD
CLiC Co-Investigator
E-mail: narkewicz.michael@tchden.org

Cara L Mack, MD
CLiC Co-Investigator
E-mail: mack.cara@tchden.org

Frederick M Karrer, MD
CLiC Co-Investigator
E-mail: karrer.frederick@tchden.org

Shikha Sundaram, MD
CLiC Co-Investigator

Mark Lovell, MD
CLiC Pathologist

Johan L Van Hove, MD, PhD
CLiC Respiratory Chain Core Director
E-mail: vanjove.johan@tchden.org

Elizabeth Esterl, RN, MS, CCRC
CLiC Study Coordinator
E-mail: esterl.elizabeth@tchden.org
720.777.8430

Hazel Senz, RN, CRC
CLiC Study Coordinator
E-mail: senz.hazel@tchden.org
720.777.5380

Joan M. Hines, MPH
CLiC Research Administrator
E-mail: hines.joan@tchden.org
 720.777.2598

About Us:

Dr. Ronald Sokol

Dr. Sokol is the Director of the Pediatric General Clinical Research Center and Associate Medical Director of the Pediatric Liver Center. He is also a Professor and Vice Chair of Pediatrics at The University of Colorado Health Sciences Center. Dr. Sokol received his MD degree from the University of Chicago School of Medicine. He completed his pediatric training at the University of Colorado Health Sciences Center and subspecialty training at the Children's Hospital Research Foundation of Cincinnati.

Dr. Sokol has published extensively on childhood liver disease, nutrition, and oxidative stress. Dr. Sokol received the 2003 Nutrition Award from the American Academy of Pediatrics for his research on vitamin E and antioxidants. Dr. Sokol is the Chair of the Steering Committee of the NIH-supported Biliary Atresia Clinical Research Consortium. Dr. Sokol also participates in numerous other professional activities, including the Polycystic Kidney Disease Research Group Advisory Board, the Children's Digestive Health and Nutrition Foundation and the American Liver Foundation. Dr. Sokol is the recipient of numerous grant awards and is a reviewer for multiple medical journals. Dr. Sokol is on the Editorial Board of three medical journals and is an Associate Editor of two medical journals. Dr. Sokol was President of the North American Society for Pediatric Gastroenterology and Nutrition in 1996-98. His major interests are in patient care, teaching and research in children's liver disease, nutrition and liver transplantation.

Current Studies:

6001: Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis

Useful Links:

The University of Colorado at Denver and Health Sciences Center

The Department of Pediatrics Section of Gastroenterology, Hepatology and Nutrition at the University of Colorado

The Children's Hospital - Gastroenterology, Hepatology and Nutrition Program Description

The Children's Hospital - Liver Center

Publications

  1. Deutsch GH, Sokol RJ, Stathos TH,. Knisely AS. Proliferation to paucity: evolution of bile duct abnormalities in a case of Alagille syndrome. Pediatric and Developmental Pathology 2001;4:559-563.
  2. Feranchak AP, Gralla J, King R, Ramirez RO, Corkill M, Narkewicz MR, Sokol RJ. Comparison of Indices of Vitamin A Status in Children with Chronic Liver Disease. Hepatology (In Press)
  3. Feranchak AP, Ramirez RO, Sokol RJ. Medical and nutritional management of cholestasis. In: Suchy F, Sokol RJ, Balistreri WF (eds). Liver Disease in Children , 2 nd Edition , Lippincott, Williams &Wilkins, Phildelphia, 2001; pp. 195-238.
  4. Gillis LA, Sokol RJ. Gastrointestinal Manifestations of Mitochondrial Disease. Gastroenterol Clin North Am 2003;32:789-817
  5. Hoffenberg EJ, Narkewicz MR, Sondheimer JM, Smith DJ, Silverman A, Sokol RJ: Outcome of syndromic paucity of interlobular bile ducts (Alagille syndrome) presenting in infancy with cholestasis. J Pediatr 1995; 127: 220-224
  6. Kurbegov AC, Setchell KDR, Haas J, Mierau G, Narkewicz MR, Bancroft JD, Karrer FM, Sokol RJ. Biliary Diversion for Progressive Familial Intrahepatic Cholestasis: Improved Liver Morphology and Bile Acid Profile. Gastroenterology 2003;125:1227-1234
  7. Narkewicz MR, Smith D, Gregory C, Lear J, Osberg I, Sokol RJ. Effect of ursodeoxycholic acid therapy on hepatic function in children with intrahepatic cholestatic liver disease. J Pediatr Gastroent Nutr 1998, 26:49-55.
  8. Narkewicz MR, Sokol RJ, Beckwith B, Sondheimer J, Silverman A: Liver involvement in Alpers disease. J Pediatr 119:260-267, 1991.
  9. Narkewicz MR: Neonatal Cholestasis: Pathophysiology, Etiology and Treatment. IN : Polin RA, Fox WW, Abman SH (eds), Fetal and Neonatal Physiology pp 1218-1221, Saunders, Philadelphia PA, 2004 3 rd edition.
  10. Setchell KDR, Schwarz M, O'Connell NC, Lund EG, Davis DL, Lathe R, Thompson HR, Tyson RW, Sokol RJ, Russell DW. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7a-hydroxylase gene causes severe neonatal liver disease. J Clin Invest 1998;102:1690-1703.
  11. Setchell KDR, Schwarz M, O'Connell NC, Lund EG, Davis DL, Lathe R, Sokol RJ, Russell DW. A mutation in the oxysterol 7 a -hydroxylase gene causes severe liver disease and highlights the quantitative importance of the acidic pathway for bile acid synthesis in humans. Proceedings of Falk Symposium No. 108, "Bile acids and cholestasis", Kluwer Academic Publishers, Lancaster , England , 1999; pp. 213-219.
  12. Shneider B, Rinaldo P, Emre S, Bucuvalas J, Squires R, Narkewicz M, Gondolesi G, Magid M, Morotti R, Hynan L and the Pediatric Acute Liver Failure Study Group. Abnormal concentrations of esterified carnitine in bile: A feature of pediatric acute liver failure with poor prognosis. Hepatology 41:717-721, 2005.
  13. Sokol RJ, Butler-Simon N, Conner C, Heubi JE, Sinatra FR, Suchy FJ, Heyman MB, Perrault J, Rothbaum RJ, Levy J, Iannaccone ST, Shneider BJ, Koch TK, Narkewicz MR: Multicenter trial of d-?-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology 104:1727-1735, 1993.
  14. Sokol RJ, Dahl R, Devereaux MW, Yerushalmi B, Gumpricht. Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. J Pediatr Gastroenterol Nutr 2005;41:235-43.
  15. Sokol RJ, Narkewicz MR: Mitochondrial hepatopathies. IN: Suchy FJ (ed) Liver Disease in Children, pp 888-896. Mosby, St. Louis , 1994.
  16. Sokol RJ, Treem W. Mitochondrial hepatopathies. In: Suchy F, Sokol RJ, Balistreri WF (eds). Liver Disease in Children, 2 nd Edition, Lippincott, Williams &Wilkins, Philadelphia, 2001; pp. 787-810.
  17. Sokol RJ, Treem WE. Mitochondria and childhood liver diseases. J Pediatr Gastroenterol Nutr. 1999;28:4-16.
  18. Sokol RJ. Metabolic diseases of the liver. Chapter 113, In: Yamada T (ed). Textbook of Gastroenterology and Hepatology. Lippincott Williams & Wilkins, Philadelphia. 2003:2397-2415.
  19. Suchy F, Narkewicz MR: Development of the liver and bile ducts. IN: Sokol RJ (ed), Pediatric Liver Research Agenda 2000: A Blueprint for the Future, pp 15-19. The American Liver Foundation, NY, NY, 2000 (http://www.liverfoundation.org/html/advores.htm).
  20. Treem WR, Sokol RJ. Disorders of mitochondria. Sem Liv Dis 1998;18:237-253.
  21. Vu TH, Tanji K, Holve SA, Bonilla E, Sokol RJ, Snyder RD, DiMauro S, De Vivo D. Navajo neurohepatopathy: a mitochondrial DNA depletion syndrome? Hepatology 2001 34:116-120
  22. Yerushalmi B, Sokol RJ, Narkewicz MR, Smith D, Karrer FM: Use of rifampin for severe pruritus in children with chronic cholestasis. J Pediatr Gastroenterol Nutr 29:442-447, 1999.
  23. Yerushalmi BY, Sokol RJ, Narkewicz MR, Smith D, Ashmead JW, Wenger DA: Niemann-Pick disease type C in neonatal cholestasis at a North American center. J Pediatr Gastroenterol Nutr 35:44-50, 2002