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CLiC Cholestatic Liver Disease Consortium |
Mount Sinai Medical Center |
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The Mount Sinai Medical Center Web Site
Contact Information:
Frederick J. Suchy, MD
CLiC Principal Investigator
E-mail: Frederick.Suchy@mssm.edu
Raffaella Morotti, MD
CLiC Pathologist
Nanda Kerkar, MD
E-mail: nanda.kerkar@mountsinai.org
Sanobar Parkar
CLiC Study Coordinator
E-mail: sanobar.parkar@msnyuhealth.org
212.659.8046
About Us:
Frederick J. Suchy, M.D. is the Herbert H. Lehman Professor and Chair of the Department of Pediatrics and Pediatrician-in-Chief at Mount Sinai School of Medicine. Dr. Suchy's research has focused on hepatic transport mechanisms which contribute to bile formation and which may be altered during cholestatic liver disease. He has studied the development and regulation of liver basolateral and canalicular transport proteins for bile salts. In more recent years, he has been interested in the role of nuclear receptors in regulating bile acid transporters and the membrane polarity of these transporters in both liver and intestine.
Dr. Suchy has held numerous national leadership positions critical to clinical practice and research in pediatric gastroenterology and hepatology. He has served on the Subboard in Pediatric Gastroenterology of the American Academy of Pediatrics and on the Accreditation Council for Graduate Medical Education for Pediatric Gastroenterology. He has been member and Chair of the Research Committees of both the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the American Association for the Study of Liver Diseases (AASLD). He has served on the Executive Council of both organizations. In 1994, he became President of NASPGHAN and is completing a year as the President of AASLD, only the second pediatrician in the over 50-year history of this organization to serve in this capacity. While President of NASPGHAN, he initiated the Young Investigator Grants Program which has grown over the last decade and has been very successful in fostering the initial research of outstanding physician/scientists in pediatric gastroenterology. He continues to serve on the Children's Liver Council of the American Liver Foundation, and was recently appointed to the Governing Board of the Children's Digestive Health and Nutrition Foundation. He has been a member of and served as Chair of the General Medicine A Study Section of the NIDDK. In addition to the SPR and APS, Dr. Suchy is a member of the American Society for Clinical Investigation and the Association of American Physicians.
Useful Links:
Mount Sinai School of Medicine
Recanati/Miller Transplantation Institute
Mount Sinai Medical Center - Find a Doctor
Publications:
Shneider B, Setchell K, Whitington P, Neilson K, Suchy F.
Delta4-3-oxosteroid 5ß-reductase deficiency causing neonatal liver failure and hemochromatosis. J Ped 124:234-238, 1994.
Shneider B. A New Era in Bile Acid Transport Pathophysiology (selected summary). J. Pediatr. Gastroenter. Nutr. 26:236-237, 1998.
Shneider B.; Genetic Cholestasis Syndromes. J. Pediatr. Gastorenter. Nutr. 28:124-131, 1999.
Morton D, Salen G, Batta A, Shefer S, Tint G, Belchis D, Shneider B, Bull L, Knisely A.Abnormal hepatic sinusoidal bile acid transport in an Amish kindred is not linked to mutation in FIC1 and is improved by ursodiol. Gastroenterology 119:188-195, 2000.
Shneider B.; Intestinal bile acid transport: Biology, physiology and pathophysiology. J. Pediatr. Gastroenterol Nutr. 32:407-417, 2001.
Al-Ansari N, Shneider B.; Flipping over flippases (selected summary). J. Pediatr. Gastroenterol. Nutr. 33:102-103, 2001.
Brennan S, Maghzal G, Shneider B, Gordon R, Magid M, George P. Novel fibrinogen _375 Arg->Trp mutation (Fibrinogen Aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Hepatology 36:652-658, 2002.
Suchy FJ. Clinical problems with developmental anomalies of the biliary tract.
Semin Gastrointest Dis. 2003 Oct;14(4):156-64.
Suchy FJ, Burdelski M, Tomar BS, Sokol RJ. Cholestatic liver disease: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2002;35 Suppl 2:S89-97.
Carlton V, Harris B, Puffenberger E, Batta A, Knisely A, Shneider B, Lim W, Salen G, Morton H, Bull L. Complex inheritance of familial hypercholanemia with associated mutations in ZO-2 and BAAT. Nature Genetics 34:91-96, 2003.
Neimark E, Shneider B. Novel surgical and pharmacological approaches to chronic cholestasis. J. Pediatr. Gastroenterol. Nutr. 36:296-297, 2003.
Zhu Q, Xing W, Qian B, von Dippe P, Shneider B, Fox V, Levy D. Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Biochim. Biophys. Acta 1638:208-216, 2003.
Shneider B. Progressive intrahepatic cholestasis: Mechanisms, diagnosis and therapy. Pediatr. Transplantation 8:609-612, 2004.
Chen F, Ananthanarayanan, M, Emre S, Neimark E, Bull L, Knisely A, Strautnieks S, Thompson R, Magid M, Gordon R, Balasubramanian N, Suchy F, Shneider, B. Progressive Familial Intrahepatic Cholestasis, Type 1, is Associated with Decreased Farnesoid X Receptor Activity. Gastroenterology 126:756-764, 2004.
Suchy FJ. Neonatal cholestasis. Pediatr Rev. 2004 Nov 25(11):388-96.
Balistreri W, Bezerra J, Jansen P, Karpen S, Shneider B, Suchy F. Intrahepatic cholestasis: Summary of an AASLD Single Topic Conference Hepatology (in press).
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