Information for Patients

Bronchiolitis Obliterans Syndrome

Do you or someone you know have chronic graft-versus-host disease (chronic GVHD) affecting the lungs (the doctor may also have called this “bronchiolitis obliterans syndrome” or “BOS”)? If this diagnosis was made less than 6 months ago, you may be eligible to participate in a research study to test the effectiveness of a three-drug combination called “FAM” because participants take Fluticasone by inhaler, Azithromycin pills by mouth, and Montelukast pills by mouth) to treat BOS and decrease the need for steroid medications.

This study is being conducted by researchers at institutions across the country, and they are currently looking for patients to enroll in the trial. Learn More About Joining Bronchiolitis Obliterans Research >

What is bronchiolitis obliterans syndrome?

Bronchiolitis obliterans syndrome is a type of chronic GVHD that causes damage to small air passages in the lungs.

Who gets bronchiolitis obliterans syndrome?

Damage to small air passages occurs in about 10% of patients with chronic GVHD.

What causes bronchiolitis obliterans syndrome?

The answer to this question is not known.

How is bronchiolitis obliterans syndrome diagnosed?

Bronchiolitis obliterans syndrome is diagnosed by a combination of tests. Pulmonary function tests (PFTs) show decreased ability to exhale air from the lungs. Three-dimensional x-rays (CAT scans) show trapping of air in the lungs. Additional tests are usually done to be sure that these changes are not caused by infection.

What is the treatment for bronchiolitis obliterans syndrome?

Prednisone or other similar anti-inflammatory or immunosuppressive medications are used to treat bronchiolitis obliterans syndrome. Bronchiolitis obliterans syndrome is often treated with an inhaled form of a medication like prednisone.