Roy Freeman, MD
Director of the Center for Autonomic and Peripheral Nerve Disorders
Beth Israel Deaconess Medical Center, Harvard Medical School
Dr. Freeman and his colleagues and collaborators have developed and refined techniques, including time and frequency domain measures of heart rate, blood pressure, cerebral flow, cutaneous blood flow control, baroreflex function and sudomotor function. They have harnessed these techniques to understand the pathophysiology of diabetic peripheral neuropathy, the autonomic neuropathy of HIV infection and amyloid neuropathy, MSA and PAF. Building on work carried out by the Vanderbilt Autonomic Group and in collaboration with Dr. Horacio Kaufmann in projects sponsored by the FDA orphan Dr.ug program and NORD, they have carried out mechanistic and therapeutic studies with the norepinephrine precursor, Dr.oxidopa, to treat neurogenic orthostatic hypotension. This agent is now in a multicenter clinical trial.