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University of Pennsylvania Perelman School of Medicine (Penn Medicine)

Philadelphia, Pennsylvania


About the Center

Penn Gastroenterology (GI) is a national leader in the diagnosis and treatment of gastrointestinal diseases and disorders. We combine the latest technological advancements with the expertise of our renowned physicians, improving the health and quality of life for those with digestive system disorders. Penn Gastroenterology is at the forefront of GI patient care, education, and research. We care for approximately 200 patients diagnosed with Eosinophilic Esophagitis. In addition to caring for adults with eosinophilic esophagitis, our joint Penn-CHOP Center for Digestive, Liver and Pancreatic Medicine is the only one in the country with a specific focus on transitioning children with eosinophilic esophagitis to adult gastroenterology care. Our goal is to provide inter-disciplinary care (gastroenterologists, allergists, nutritionists and others) together to deliver state of the art care and access to clinical trials to all patients with eosinophilic esophagitis as they make the transition from adolescence to young adulthood (age 18). This unique program offers our patients a unified approach from both pediatric and adult practitioners. Equally important goals include understanding the biology of EoE and genetics through basic, translational and clinical research. Through CEGIR we hope to improve the lives of all patients with eosinophilic gastrointestinal disorders.

Penn Medicine main website
Gastroenterology Division at Penn Medicine website

Related research studies at this Center:
Division of Gastroenterology, Penn Medicine Research and Clinical Trials website

Center Personnel



UPenn Contact Information



The Children’s Hospital of Philadelphia (CHOP)

Philadelphia, Pennsylvania


About the Center

The Center for Pediatric Eosinophilic Disorders was established in 2006 making it one of the first EGID centers in the United States. The Center at CHOP, along with its collaborating center at Hospital at University of Pennsylvania (HUP) with its transition program through the Joint Center for Adult-Pediatric GI, provides a continuity of care from pediatric to adults of all ages. The Center has a long-established program in basic, translational and clinical research. The Center has pioneered the use of diet in EoE and led the clinical trial of anti-IL5 for the treatment of EoE. We have developed basic science mouse models for EoE identifying key pathways. In collaboration with the CHOP Center for Applied Genomics, we have identified 4 novel genes that provide risk factors for EoE. We have also successfully trained numerous fellows for successful clinical and academic careers in allergy and gastroenterology.

The centers at CHOP and HUP are participating in the CEGIR clinical trials, and Dr. Spergel is acting as the PI for the CEGIR Training (Career Development) Program.

CHOP main website
Division of Allergy at CHOP website
Center for Pediatric Eosinophilic Disorders website
The Joint Penn-CHOP Center for Digestive, Liver and Pancreatic Medicine website

Center Personnel



CHOP Contact Information