Scientists at Cincinnati Children’s Hospital Medical Center have uncovered three distinct subtypes of eosinophilic esophagitis (EoE), an emerging food allergic disease. The discovery provides a framework for developing precision medicines to treat this often debilitating disorder.
The scientists studied biopsies of 185 children and adults at 10 sites associated with the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). The three EoE groups that they identified were consistent across children and adults and the three types ranged from mild to severe. Each subtype was associated with different clinical features and molecular pathways, and the researchers identified genes that are altered within each EoE group.
Click on the link below to listen to the senior author of the study article, Dr. Marc Rothenberg, discuss this study with the Lancet Journal: https://www.thelancet.com/doi/story/10.1016/audio.2018.06.06.107090#.WyEw77zvzB0.email
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