5505: Longitudinal Protocol for Granulomatosis with Polyangiitis (Wegener's) and Microscopic Polyangiitis

Status: Recruiting

Summary

In the longitudinal studies, clinical and laboratory information will be collected on patients with vasculitis to study the disease over an extended period of time. The data from the longitudinal studies will be used by scientists to study the genetics and causes of vasculitis, find new ways to track disease and predict responses, to understand how to treat patients, and much more.

Target Enrollment

A total of 1200 patients with AAV (800 GPA, 400 MPA) will be enrolled.

Patients will have disease in various stages and of different duration. Widely accepted diagnostic criteria-as opposed to classification criteria or definitions-have not yet been developed for Granulomatosis with Polyangiitis (Wegener's). The Granulomatosis with Polyangiitis (Wegener's) Etanercept Trial employed a modification of the American College of Rheumatology (ACR) Criteria for the classification of GPA in its eligibility criteria.

In summary, in order to be included, GPA patients will need to meet at least 2 of the 5 modified ACR Criteria for the classification of GPA. MPA patients will need to meet the Chapel Hill Consensus Conference definition of MPA. In addition, in cases of patients diagnosed with either GPA or MPA, a lengthy list of mimickers must be excluded.

How to participate

In order to participate in a study, you must personally contact the study coordinator of any of the participating institutions by phone or by e-mail. Please use the information below to inquire about participation.

United States

Massachusetts

  • Boston University School of Medicine, Boston
    Naomi Amudala
    Study Coordinator
    E-mail: namudala@bu.edu
    Phone: 617-358-6796

Minnesota

  • Mayo Clinic College of Medicine, Rochester
    Samantha Hughes
    Study Coordinator
    E-mail: hughes.samantha@mayo.edu
    Phone: 507-266-1026

Ohio

  • Cleveland Clinic Foundation, Cleveland
    Elizabeth Kisela
    Study Coordinator
    E-mail: kiselae@ccf.org
    Phone: 216-444-4887

Pennsylvania

  • University of Pennsylvania, Philadelphia
    B. Minal Hatwar
    Clinical Research Coordinator
    E-mail: Bhagyavati.Hatwar@uphs.upenn.edu
    Phone: 215-614-4406
  • University of Pittsburgh, Pittsburgh
    Laurie Hope, RN
    Clinical Research Coordinator
    E-mail: hopelk@upmc.edu
    Phone: 412-648-4098

Utah

Canada

Ontario

  • St. Joseph's Healthcare, Hamilton
    Sandra Messier, RCT
    Vascular Medicine Research Coordinator
    E-mail: smessier@stjoes.ca
    Phone: 905-522-1155 Ext. 33260
     
  • University of Toronto Mount Sinai Hospital, Toronto
    Judy Vendramini
    Study Coordinator
    E-mail: judy.vendramini@sinaihealthsystem.ca
    Phone: 416-586-4800 Ext. 5511