Glossary of Common Terms

Terms that may be seen frequently in TAPIR trial materials

Active Disease:
A person's vasculitis is considered to be active when the disease is causing symptoms, lab test abnormalities, or other problems due to the ongoing vasculitis processes. Problems due to established damage, medications, or other diseases are not considered part of active disease. By definition, patients in remission do not have any active disease
Consent Form:
a written document given to potential participants that explains the methods, benefits and risks of a trial. Consent forms must be presented to a potential trial participant and signed before that person can take part in the trial.
Flare:
a disease flare represents recurrence of inflammatory activity of the underlying vasculitis after a state of remission has been achieved with treatment.
Some additional notes about flares:
Usually disease flares are milder than the original disease presentation because the patient may still be on some immunosuppressive therapy that muffles the intensity of the inflammation or because symptoms get recognized faster by the patients and their physicians, and a renewed course of remission induction therapy is implemented earlier.
Disease flares do not always occur in the same way as the disease originally presents. The rule of thumb is that the sooner a relapse occurs (the shorter the time of remission has been), the more likely the relapse will be similar to the original disease presentation. In contrast, relapses occurring after several years in stable, possibly drug-free remission have a higher likelihood to present differently and involve other organs than those originally afflicted. These patterns certainly do not always occur.
Immuno-suppressive Drugs:
medications that reduce the functioning of a person's immune system. These drugs are used to reduce inflammation and other actions of the immune system. Examples of immunosuppressive drugs often used for vasculitis include prednisone, azathioprine, cyclophosphamide, methotrexate, mycophenolate, rituximab and others.
Participant:
a (trial) participant is a person who is actively taking part in a research trial.
Prednisone:
a synthetic corticosteroid that suppresses the body's response to inflammatory diseases.
Relapse:
worsening of symptoms after a period of improvement
Remission:
a state or period during which there is absence of disease activity.
Standard of Care:
medical practice, including treatments and testing, that is considered to be the usual and appropriate approach to care; the type of medical care practiced by the majority of doctors treating a given condition.
Taper:
to reduce or lower a dose of a medication gradually.
Vasculitis:
any of several diseases involving inflammation of a blood or lymph vessels

Vasculitis Foundation

Vasculitis medical term glossary

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  • Must currently be in remission
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