Consortium Spotlight: Advancing Discoveries in Charcot-Marie-Tooth Disease Dakota Campbell Tue, 08/09/2022 - 10:02
Inherited Neuropathy Consortium logo

The Inherited Neuropathy Consortium (INC) is a group of academic medical centers, patient advocacy organizations, and clinical research resources dedicated to conducting clinical research in Charcot-Marie-Tooth disease, a group of disorders that affect the peripheral nerves. Here, program manager Shawna Feely, MS, LGC, and principal investigator Michael Shy, MD, share the history of the consortium, current research, and future plans. 

Former Inherited Neuropathy Consortium Scholar Publishes on Genetics of Charcot Marie Tooth (CMT) Disease sheila.wolfer@… Tue, 06/22/2021 - 08:13
Brett McCray, MD, PhD
Brett McCray, MD, PhD

Mentorship and investment in early-career researchers pays off

Recent research published in Nature Communications offers new insights into the genetics of inherited neuropathy and Charcot Marie Tooth (CMT) disease, a degenerative nerve disease that usually manifests with weakness and sensation loss in the feet and hands. Lead author Brett McCray, MD, PhD, from Johns Hopkins Medicine and his colleagues identified the small GTPase RhoA as a novel binding partner for TRPV4 and found that neuropathy mutations in TRPV4 completely disrupted RhoA binding.