Washington University in Saint Louis

St Louis Children's Hospital
Thomas Ferkol, MD
PCD Center Director
314-454-2694
314-454-2515 fax

Barnes-Jewish Hospital
Jeffrey Atkinson, MD

Adult PCD Center Director
314-454-8640
314-454-5919 fax

 

Contact Information:

Jane Quante, RN
Research Coordinator
Washington University in St. Louis
660 South Euclid Avenue
Campus Box 8116
St. Louis, MO 63110
314-454-2353
314-454-6241 fax

 

About Us:

For more than a century, the Washington University School of Medicine and its teaching hospitals, Barnes-Jewish Hospital and St. Louis Children's Hospital, has educated leading physicians and scientists, and is committed to excellence in patient care, basic and clinical research, and teaching.

Children's Hospital Logo St. Louis Children's Hospital

Image of the Saint Louis Children's HospitalThe Division of Pediatric Allergy and Pulmonary Medicine at St. Louis Children's Hospital has a strong commitment to training, research, and clinical care. During the past few years, the Division has experienced remarkable growth in many areas, and its faculty has gained a national and international reputation for its basic scientific investigations and clinical expertise.

In our Division you will find:

  • one of eight centers participating in the National Institutes of Health Childhood Asthma Management Program (CAMP) that is investigating the long-term effects of anti-inflammatory agents and alternative therapies on pulmonary function,
  • a pediatric cystic fibrosis center that cares for more than 300 patients and is participating in numerous clinical research projects through the Cystic Fibrosis Foundation.
  • Therapeutic Development Network
  • a pediatric lung transplantation program that cares for the largest group of lung and heart-lung transplant children in North America,
  • a bronchoscopy center where more than four hundred procedures are performed annually,
  • a modern pulmonary function laboratory proficient in performing both pediatric and infant studies.
Barnes Jewish Hospital Logo Barnes-Jewish Hospital

Image of the Barnes Jewish HospitalBarnes-Jewish Hospital, in partnership with lung specialists at Washington University School of Medicine, stands committed to providing patients with useful, up-to-date information about lung disease and its treatment. The Barnes-Jewish Hospital pulmonary program is known for its team approach to compassionate, expert care. Physicians and staff members from various disciplines work together, providing the latest clinical expertise. Each year, more than 10,000 patients and 5,000 outpatients come to Barnes-Jewish Hospital to receive the best in lung disease care. In our Division you will find:

  • Barnes-Jewish Hospital was recently ranked sixth nationally in respiratory disorders by U.S. News & World Report.
  • leaders in the research and development of molecular medicine for the diagnosis and treatment of lung disease.
  • nationally recognized leaders in lung transplantation, with more than 750 adult transplants performed.
  • a comprehensive new outpatient facility, the Jacqueline Maritz Lung Center for outpatient diagnosis and treatment of all respiratory disorders.
  • A state-of-the-art pulmonary function laboratory Lab for assessing lung physiology at rest and during exercise.
  • An adult cystic fibrosis Program with over 150 patients that is accredited by the Cystic Fibrosis Foundation.

We are excited to be one of the primary centers for the Genetic Determinants of Mucociliary Clearance Consortium, part of the National Institutes of Health Rare Diseases Clinical Research Network, which we expect will better define the pathogenesis, natural history, and treatment of primary ciliary dyskinesia and atypical forms of cystic fibrosis.

 

Useful Links:

Map of Hospital Campus

St Louis Children's Hospital

Barnes-Jewish Hospital

BJC Health Systems

Washington University in St. Louis

 

Publications

Brody SL, Yan XH, Wuerffel MK, Song SK, Shapiro SD. Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol. 2000;23:45-51.

Brody SL.  Genetic regulation of cilia assembly and the relationship to human disease. Am J Respir Cell Mol Biol. 2004;30:435-7.

Casey B, Hackett BP. Left-right axis malformations in man and mouse. Curr Opin Genet Dev. 2000;10:257-61.

Dutcher SK. Chlamydomonas reinhardtii: biological rationale for genomics. J Eukaryot Microbiol. 2000;47:340-9.

Dutcher SK. Flagellar assembly in two hundred and fifty easy-to-follow steps. Trends Genet. 1995;11:398-404.

Ferkol TW and Davis PB. "Bronchiectasis and Bronchiolitis Obliterans" in L.M. Taussig and L.I. Landau, editors: Textbook of Pediatric Respiratory Medicine. St. Louis, Missouri. Mosby Year Book. pp. 784-793. 1998.

Gomperts BN, Gong-Cooper X, Hackett BP. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci. 2004;117:1329-37.

Huang T, You Y, Spoor MS, Richer EJ, Kudva VV, Paige RC, Seiler MP, Liebler JM, Zabner J, Plopper CG, Brody SL.  Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci. 2003;116:4935-45.

King SJ, Dutcher SK. Phosphoregulation of an inner dynein arm complex in Chlamydomonas reinhardtii is altered in phototactic mutant strains. J Cell Biol. 1997;136:177-91.

Li JB, Gerdes JM, Haycraft CJ, Fan Y, Teslovich TM, May-Simera H, Li H, Blacque OE, Li L, Leitch CC, Lewis RA, Green JS, Parfrey PS, Leroux MR, Davidson WS, Beales PL, Guay-Woodford LM, Yoder BK, Stormo GD, Katsanis N, Dutcher SK. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell. 2004;117:541-52.

Look DC, Walter MJ, Williamson MR, Pang L, You Y, Sreshta JN, Johnson JE, Zander DS, Brody SL. Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary function. Am J Pathol. 2001;159:2055-69.

Zhang M, Bolfing MF, Knowles HJ, Karnes H, Hackett BP.  Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun. 2004;324:1413-20.