Diseases Studied
The Rare Diseases Clinical Research Network is an NIH-funded research network of 21 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
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All Diseases > STAT3-related hyper-IgE syndrome
STAT3-related hyper-IgE syndrome
Alternative Names: Hyper-IgE syndrome, HIES, Job syndrome, autosomal dominant hyper IgE syndrome (AD-HIES)
Disease Category: Bronchiectasis
STAT3-related hyper-IgE syndrome, also known as autosomal dominant hyper-IgE syndrome is a rare inherited condition that affects the immune system and the development of certain tissues in the body. People with AD-HIES have difficulty fighting some infections, particularly those involving the skin and lungs, which often begin in childhood and may be severe or slow to heal.