The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
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All Diseases > Idiopathic Bronchiectasis
Idiopathic Bronchiectasis (IB)
Disease Category: Genetic Mucociliary Disorders
A progressive disorder in which the bronchi (air passages within the lungs that diverge from the windpipe) are permanently dilated (enlarged) and irreversibly scarred. This occurs without a known underlying cause such as recurrent infections, inflammation, aspiration, immunodeficiencies, ciliary abnormalities, or genetic mutations. Symptoms include chronic coughing, hemoptysis (coughing up blood), weight loss, chest pain or tightness, dyspnea (shortness of breath), wheezing, nail clubbing, and fatigue.