Diseases Studied

The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.

This network focuses on clinical research and does not generally support clinical care outside of research activities. To learn about other rare diseases, please visit the Genetic and Rare Diseases Information Center (GARD), which is an NIH program that helps the public find reliable information about rare and genetic diseases. Their staff are specialists. Contact them at 1-888-205-2311 or email GARDinfo@nih.gov.

All Diseases > Microscopic Polyangiitis

Microscopic Polyangiitis (MPA)

Disease Category: Vasculitis Disorders

A rare disorder characterized by blood vessel inflammation, most commonly affecting the kidneys, lungs, nerves, joints, and skin. The cause of the disorder is poorly understood, but may occur due to gene mutations, infections, or autoimmune (body attacking itself) disorders. Symptoms include skin lesions, muscle and joint pain, fatigue, weakness, fever, sensory changes due to nerve damage, weight loss, leg swelling, dark urine, cough, difficulty breathing, and ear, eye, and sinus problems.

Research groups studying this disease

Vasculitis Disorders
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Vasculitis Clinical Research Consortium (VCRC)

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Supports and advances the cause of vasculitis patients, researchers, and healthcare professionals.