The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
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All Diseases > Polyarteritis Nodosa
Polyarteritis Nodosa (PAN)
Disease Category: Vasculitis Disorders
A rare, multisystemic disorder characterized by widespread blood vessel inflammation, weakening, and damage, specifically to small- and medium-sized arteries. The kidneys, heart, muscles, intestines, and nervous system are affected, causing high blood pressure, aneurysms (weakened areas in artery walls), blood clots, joint and muscle pain, kidney disease, and tissue damage or necrosis (tissue death) due to blocked blood flow.