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All Diseases > Sensory Ataxia Neuropathy Dysarthria and Ophthalmoplegia
Sensory Ataxia Neuropathy Dysarthria and Ophthalmoplegia (SANDO)
Alternative Names: Sensory Ataxia Neuropathy Syndrome, SANDO, Sensory Ataxic Neuropathy-Dysarthria-Ophthalmoparesis Syndrome
Disease Category: Mitochondrial Disorders
A rare, inherited disorder caused by depletion (fewer) or deletions (fragmented) DNA within mitochondria (specialized cell structures that produce energy) in skeletal muscles and limb nerves. It is characterized by abnormal sensations such as tingling, numbness, or pain in the arms and legs, ataxia (lack of coordination), generalized muscle weakness, seizures, ptosis (eyelid drooping), ophthalmoplegia (eye muscle weakness), dysarthria (speech impairment due to muscle weakness), vision loss, migraines, liver disease, cognitive impairment, depression, and myoclonus (muscle twitches).
Research groups studying this disease
North American Mitochondrial Disease Consortium (NAMDC)
Improves quality of life for people affected by mitochondrial disease through education, outreach, advocacy, and clinical research initiatives.
Promotes research and education for the diagnosis, treatment, and cure of mitochondrial disorders while providing support to those affected.