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All Diseases > Enterovirus
Alternative Names: Non-polio Enteroviruses (NPEV)
Disease Category: Congenital Infections
A virus spread through direct contact with infected bodily fluids, causing mild to severe flu-like symptoms. Infants and children are most at-risk, followed by immunocompromised adults. Rarely, newborn infants infected at birth develop sepsis, which may lead to liver transplantation, heart damage, or death.
Research groups studying this disease
Congenital and Perinatal Infections Consortium (CPIC)
8601: Neonatal Enterovirus and Human Parechovirus Viral Sepsis: Natural History and Predictors of Morbidity and Mortality (DMD 19-0026)
The purpose of this study is to get a better understanding of what causes neonatal viral sepsis and to assess the impact of the infection on the babies’ health over time. Enterovirus (EV) or human parechovirus (HPeV) are very common viruses that can cause neonatal viral sepsis. Information gained from this study may guide diagnosis and treatment of babies with neonatal viral sepsis in the future. This study will observe babies with neonatal EV or HPeV sepsis to assess and characterize the complications affecting them. The study will also identify key clinical measurements and tests that help predict the health outcomes of children with neonatal EV and HPeV sepsis. Further, although EV and HPeV are common causes of neonatal viral sepsis, this study seeks to identify other unknown viruses linked to neonatal viral sepsis. The information generated by this study will lay the foundation for clinical trial studies of antiviral drugs to treat neonatal viral sepsis.