The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
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All Diseases > Aminoglycoside-Induced Deafness
Aminoglycoside-Induced Deafness (AID)
Disease Category: Mitochondrial Disorders
Sensorineural hearing loss, or permanent hearing loss caused by irreversible damage to the inner ear or the nerve that transmits signals from the brain to the ear. Onset occurs a few days to weeks following exposure to aminoglycoside antibiotics. Specific genetic mutations in mitochondria (specialized cellular structures that produce energy) predispose individuals to ototoxicity (ear poisoning by certain medications).
Research groups studying this disease
North American Mitochondrial Disease Consortium (NAMDC)View Disease Definition
Promotes research and education for the diagnosis, treatment, and cure of mitochondrial disorders while providing support to those affected.
Improves quality of life for people affected by mitochondrial disease through education, outreach, advocacy, and clinical research initiatives.