Diseases Studied

The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.

This network focuses on clinical research and does not generally support clinical care outside of research activities. To learn about other rare diseases, please visit the Genetic and Rare Diseases Information Center (GARD), which is an NIH program that helps the public find reliable information about rare and genetic diseases. Their staff are specialists. Contact them at 1-888-205-2311 or email GARDinfo@nih.gov.

All Diseases > Cerebral Cavernous Malformations

Cerebral Cavernous Malformations (CCM)

Alternative Names: Cavernous Angiomas; Cavernous Hemangiomas; Cavernomas

Disease Category: Brain Vascular Malformations

Abnormally enlarged spaces in the brain where blood collects near irregularly shaped, enlarged capillaries (tiny blood vessels) which have abnormally thin walls prone to leaking. These abnormalities may be inherited or occur sporadically in individuals with no family history. Symptoms include headaches, seizures, paralysis, hearing or vision loss, and cerebral hemorrhaging (brain bleeds).

Research groups studying this disease

Brain Vascular Malformations
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Brain Vascular Malformation Consortium (BVMC)

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Informs, supports, and mobilizes those affected and drives research for cavernous angioma (cavernoma, cerebral cavernous malformation).