Diseases Studied
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All Diseases > Complex I Deficiency
Complex I Deficiency
Alternative Names: Mitochondrial Complex I Deficiency; Complex 1 Mitochondrial Respiratory Chain Deficiency; NADH-Coenzyme Q Reductase Deficiency; NADH:Q(1) Oxidoreductase Deficiency
Disease Category: Mitochondrial Disorders
An inherited, multisystemic, mitochondrial disorder characterized by protein complex I deficiency. Shortage of this protein complex (structure made up of multiple proteins) disrupts the first step in oxidative phosphorylation, the process by which mitochondria (specialized cell structures) produce most of the body's energy. Typical manifestations include Leigh syndrome, encephalopathy (brain disease), ataxia (lack of coordination), involuntary movements, hypotonia (low muscle tone), muscle pain, weakness, seizures, exercise intolerance, fatigue, lactic acidosis (high blood lactate levels), optic nerve atrophy (wasting), and heart, kidney, or liver dysfunction.
Research groups studying this disease
Mitochondrial Disorders
North American Mitochondrial Disease Consortium (NAMDC)
MitoAction
Improves quality of life for people affected by mitochondrial disease through education, outreach, advocacy, and clinical research initiatives.
United Mitochondrial Disease Foundation
Promotes research and education for the diagnosis, treatment, and cure of mitochondrial disorders while providing support to those affected.