Diseases Studied
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All Diseases > Ceroid lipofuscinosis, neuronal, 4 (kufs type)
Ceroid lipofuscinosis, neuronal, 4 (kufs type)
Alternative Names: CLN4
Disease Category: Neuronal Ceroid Lipofuscinoses
CLN4B disease (autosomal dominant neuronal ceroid lipofuscinosis 4B) is a form of adult neuronal ceroid lipofuscinosis, which is a rare condition that affects the nervous system. Signs and symptoms usually begin around age 30, but they can develop anytime between adolescence and late adulthood. Affected people generally experience behavioral abnormalities, dementia; difficulties with muscle coordination (ataxia); and involuntary movements such as tremors or tics. It can be caused by changes in the DNAJC5 or CTSF gene and is inherited in an autosomal dominant manner.