Diseases Studied
The Rare Diseases Clinical Research Network is an NIH-funded research network of 21 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
This network focuses on clinical research and does not generally support clinical care outside of research activities. To learn about other rare diseases, please visit the Genetic and Rare Diseases Information Center (GARD), which is an NIH program that helps the public find reliable information about rare and genetic diseases. Their staff are specialists. Contact their specialists through their web form.
All Diseases > Non-candida yeasts
Non-candida yeasts
Disease Category: Fungal Diseases
Non-Candida yeast will include genera such as Cryptococcus, Trichosporon, Rhodotorula, Saccharomyces, Saprochaete, and Magnusiomyces. Each of these genera of yeast have been associated with severe illness in pediatric immune compromised patients, but very little is known about long-term outcomes, susceptibility profiles, and optimal therapeutic approaches for these pathogens. More recent epidemiology highlights that the non-Candida yeasts are more difficult to diagnose, often more resistant, and have significantly less published data to define outcomes.
Research groups studying this disease
Fungal Diseases
Pediatric Fungal Network STudy of Rare Invasive Fungal DisEases in Immunocompromised Pediatric Patients (PFN-STRIDE)
Recruiting
9601: Pediatric Fungal Network's (PFN) STudy of Rare Invasive Fungal DisEases inImmunocompromised Pediatric Patients (STRIDE) Project 1
Invasive fungal diseases (IFD) are infections caused by opportunistic fungi that are ubiquitous in the environment and often prey selectively on vulnerable populations, including patients who are immunocompromised. Although rare, IFDs are associated with significant morbidity and short-term case fatality rates of more than 30%. Current diagnostic approaches are limited. In immunocompromised children, IFDs are rarer and even more complicated to diagnose and manage than those in adults. There is a dearth of research aimed at longer term follow-up of IFD, advancing diagnostic approaches and management protocols for pediatric IFDs, and an absence of data on patient and caregiver perspectives of the impact of these infections.
The Rare Diseases Clinical Research Consortium (RDCRC) outlined in this proposal, the Pediatric Fungal Network STudy of Rare Invasive Fungal DisEases in Immunocompromised Pediatric Patients (PFN-STRIDE), will leverage an existing consortium (Pediatric Fungal Network) that is dedicated to studying IFDs in pediatric patients.