Diseases Studied
The Rare Diseases Clinical Research Network is an NIH-funded research network of 21 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
This network focuses on clinical research and does not generally support clinical care outside of research activities. To learn about other rare diseases, please visit the Genetic and Rare Diseases Information Center (GARD), which is an NIH program that helps the public find reliable information about rare and genetic diseases. Their staff are specialists. Contact them at 1-888-205-2311 or email GARDinfo@nih.gov.
All Diseases > Autosomal dominant leukodystrophy
Autosomal dominant leukodystrophy
Alternative Names: ADLD
Disease Category:
A type of leukodystrophy caused by mutations in the LMNB1 gene. Leukodystrophies are a complex, often progressive group of disorders affecting the white matter of the brain due to the loss or absence of myelin, the protective coating around nerves. ADLD typically presents in adulthood with progressive neurological symptoms, including movement difficulties, muscle weakness, and cognitive decline.
Research groups studying this disease
Leukodystrophies
Global Leukodystrophy Initiative Clinical Trials Network (GLIA-CTN)
ADLD Center
The ADLD Center’s mission is to support research into various aspects of Autosomal Dominant Leukodystrophy. They aim to enable research on pathology and therapy, while helping create a support network to disseminate relevant information. Their work includes raising ADLD awareness among physicians, scientists, and the public, supporting relevant research through grants, providing a caring and educational community for patients and their families, a serving as a unique information resource.