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Diseases Studied

The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.

This network focuses on clinical research and does not generally support clinical care outside of research activities. To learn about other rare diseases, please visit the Genetic and Rare Diseases Information Center (GARD), which is an NIH program that helps the public find reliable information about rare and genetic diseases. Their staff are specialists. Contact them at 1-888-205-2311 or email

All Diseases > Granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA)

Alternative Names: Wegener's Disease

Disease Category: Vasculitis Disorders

A rare, autoimmune (body attacking itself) disorder characterized by blood vessel inflammation, primarily affecting the lungs and kidneys. Symptoms include upper respiratory and ear infections, hearing loss, persistent runny nose and cough, nasal congestion, nosebleeds, sinus and lung inflammation, difficulty breathing, wheezing, vocal changes, fever, malaise (general discomfort), weight loss, loss of appetite, fatigue, muscle and joint pain, renal (kidney) disease, high blood pressure, leg swelling, and pleural effusion (excessive fluid accumulation in the lungs).

Research groups studying this disease

Vasculitis Disorders
VCRC logo

Vasculitis Clinical Research Consortium (VCRC)

Vasculitis Foundation Canada encourages and supports research efforts for the cause and cure for all forms of Vasculitis. 

We raise awareness of vasculitis, fund research and provide support to people with vasculitis in the UK.

Supports and advances the cause of vasculitis patients, researchers, and healthcare professionals.