The Rare Diseases Clinical Research Network is an NIH-funded research network of 20 active consortia or research groups working to advance treatment for diseases that are rare. Use the search tools on this page to find the diseases we currently study. You can reach out to the indicated consortia or research groups for more information on those diseases and studies underway.
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All Diseases > Granulomatosis with Polyangiitis
Granulomatosis with Polyangiitis (GPA)
Alternative Names: Wegener's Disease
Disease Category: Vasculitis Disorders
A rare, autoimmune (body attacking itself) disorder characterized by blood vessel inflammation, primarily affecting the lungs and kidneys. Symptoms include upper respiratory and ear infections, hearing loss, persistent runny nose and cough, nasal congestion, nosebleeds, sinus and lung inflammation, difficulty breathing, wheezing, vocal changes, fever, malaise (general discomfort), weight loss, loss of appetite, fatigue, muscle and joint pain, renal (kidney) disease, high blood pressure, leg swelling, and pleural effusion (excessive fluid accumulation in the lungs).