Congratulations to the Rare Diseases Clinical Research Network’s member Marc Rothenberg, MD, PhD for receiving the Paul Ehrlich Lectureship Award of the International Eosinophil Society (IES) for 2019. Dr. Rothenberg is the Principal Investigator for the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). The award is the highest honor bestowed by the International Eosinophil Society to an individual who has made major contributions to the advancement of our understanding of the eosinophil. The selection of Dr. Rothenberg was based on his outstanding, prolific, high-quality and broad research achievements that have substantially advanced the knowledge regarding the molecular mechanisms governing the eosinophil in health and disease.
Dr. Rothenberg’s research is focused on molecular analysis of allergic inflammation, primarily on the molecular pathogenesis of eosinophilic esophagitis. His laboratory takes a multi-disciplinary approach including the development of preclinical murine models: genetics, genomics, molecular immunology, and biochemistry. His laboratory has several broad research areas and objectives, including the epigenetic basis of allergic disease and responses, genetic basis of allergic disease, immunopathogenesis of allergic inflammation, impaired barrier function, pathogenesis of eosinophilic gastrointestinal disorders, precision and predictive medicine, and proteases and protease inhibitors in inflammation. Dr. Rothenberg will deliver the lecture at the eleventh Biennial Symposium of the International Eosinophil Society.
CEGIR represents pediatric and adult multidisciplinary research institutions from across the country who seek to determine the natural history of the rare eosinophilic gastrointestinal diseases (EGIDs), identify innovative diagnostics and novel treatments, and train the next generation of investigators in this field. EGIDs are chronic gastrointestinal inflammatory diseases that affect children and adults, causing common GI symptoms such as vomiting, abdominal pain, diarrhea, and swallowing difficulties. Treatments are limited to elimination of potentially allergenic foods and steroids.
More about the Rothenberg Lab: https://www.cincinnatichildrens.org/research/divisions/a/allergy-immunology/labs/rothenberg
More about the 2019 International Eosinophil Society Symposium: http://www.eosinophil-society.org/symposia/2019-biennial-symposium
More about CEGIR: https://www.rdcrn.org/cegir